Schematic representation of the methodologies steps projected in NeuroStimSpinal

According to this methodology, the objectives are:

- Formulation of different adECM/GBM compositions, shapes and porosity matrices rationally designed for different SCI locations

- Assess the biocompatibility, bio-functionality, performance (including electrical stimulation) of adECM/GBM scaffolds using embryonic neural progenitor cells (ENCPs)

- Evaluate the systemic and long-term efficacy of cell-laden and non-cell-laden scaffolds with and without electrical stimulation using rat and rabbit in vivo models