Methodology
Schematic representation of the methodologies steps projected in NeuroStimSpinal
According to this methodology, the objectives are:
According to this methodology, the objectives are:
- Formulation of different adECM/GBM compositions, shapes and porosity matrices rationally designed for different SCI locations
- Formulation of different adECM/GBM compositions, shapes and porosity matrices rationally designed for different SCI locations
- Assess the biocompatibility, bio-functionality, performance (including electrical stimulation) of adECM/GBM scaffolds using embryonic neural progenitor cells (ENCPs)
- Assess the biocompatibility, bio-functionality, performance (including electrical stimulation) of adECM/GBM scaffolds using embryonic neural progenitor cells (ENCPs)
- Evaluate the systemic and long-term efficacy of cell-laden and non-cell-laden scaffolds with and without electrical stimulation using rat and rabbit in vivo models
- Evaluate the systemic and long-term efficacy of cell-laden and non-cell-laden scaffolds with and without electrical stimulation using rat and rabbit in vivo models